Vitamin D Status in Newborns and Risk of MS in Later Life

Most Americans are deficient in Vitamin D. We have become terrified of getting skin cancer. BUT, LACK of Vitamin D leads to cancer because we need it to build an immune system.  You need sun on BARE Skin everyday.  It needs to be on skin that hasn’t been stripped of oils. I use no soap on my skin, only a loofah.  Then DO NOT shower immediately upon coming indoors. Vitamin D is absorbed from the oil on the skin over the coarse of a few hours.

Babies born with low levels of vitamin D may be more likely to develop multiple sclerosis (MS) later in life than babies with higher levels of vitamin D, according to a study published in the November 30, 2016, online issue of Neurology®, the medical journal of the American Academy of Neurology.

“More research is needed to confirm these results, but our results may provide important information to the ongoing debate about vitamin D for pregnant women,” said study author Nete Munk Nielsen, MD, MSc, PhD, of the State Serum Institute in Copenhagen, Denmark.

In Denmark, dried blood spots samples from newborn screening tests are stored in the Danish National Biobank. Researchers identified everyone in Denmark who was born since April 30, 1981, had onset of MS by 2012 and whose dried blood spots samples were included in the biobank. The blood from those 521 people was then compared to that of 972 people of the same sex and birthday who did not have MS. In this study, newborns with levels of vitamin D less than 30 nanomoles per liter (nmol/L) were considered born with deficient levels. Levels of 30 to less than 50 nmol/L were considered insufficient and levels higher than or equal to 50 nmol/L were considered sufficient.

The study participants were divided into five groups based on vitamin D level, with the bottom group having levels of less than 21 nmol/L and the top group with levels higher than or equal to 49 nmol/L. There were 136 people with MS and 193 people without MS in the bottom group. In the top group, there were 89 people with MS and 198 people without the disease. Those in the top group appeared to be 47 percent less likely to develop MS later in life than those in the bottom group.

Nielsen emphasizes that the study does not prove that increasing vitamin D levels reduces the risk of MS.

The study has several limitations. Dried blood spots samples were only available for vitamin D analysis for 67 percent of people with MS born during the time period. Vitamin D levels were based on one measurement. Study participants were 30 years old or younger, so the study does not include people who developed MS at an older age. In addition, the Danish population is predominantly white, so the results may not be generalizable to other populations. Furthermore, it cannot be excluded that this apparent beneficial effect could be mediated through other factors in later life such as vitamin D levels, in which case a possible maternal vitamin D supplementation would not reduce the MS risk in the offspring.

Sources of vitamin D are diet, supplements and the sun. Dietary vitamin D is primarily found in fatty fish such as salmon or mackerel. Levels of vitamin D should be within the recommended levels, neither too low nor too high.

Story Source:

Materials provided by American Academy of Neurology (AAN). Note: Content may be edited for style and length.

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The Surprising Connection Between Whey Protein And Acne

You probably know my stance on dairy, that it has no place in a humans body. 

From Self

After a workout, many of us scoop some protein powder into a smoothie or scarf down a protein bar to get some quick fuel on-the-go. It’s convenient nutrition that tides you over until you can sit down for a legit meal. But recent research is suggesting that most people’s go-to protein, whey, isn’t as good for skin as it is for muscles. In fact, the milk-derived protein has been linked to acne breakouts.

A few studies done in the past five years have linked whey protein and acne. “The hardcore evidence is skimpy,” Hilary Baldwin, M.D., acne expert and medical director of the Acne Treatment and Research Center in Morristown, New Jersey, tells SELF, but the findings, mixed with anecdotal evidence, present a strong case for eliminating whey if stubborn acne is an issue.

The studies done were small—like, 30 patients or fewer small—but found that many people’s skin cleared up when they cut whey protein from the diet, or conversely, acne increased when adding in whey. Even those whose acne didn’t clear up with traditional meds, including isotrentinoin (Accutane), started to see results. “They failed to respond to traditional therapy until whey protein was discontinued,” says Baldwin.

The reason whey may cause acne is unknown, but there are a few theories. Studies have suggested connection between dairy in general and acne, specifically low or nonfat dairy, which points to whey as a potential culprit. “Whey is a part of milk. It’s mostly what’s left in a skim product,” Baldwin says. After the fat is skimmed off to make cream and the curds removed to make cheese, the liquid whey is what’s left. “That’s what gets dried out and made into [protein] powder,” Baldwin explains.

“If whey does cause acne, one of the theories is that it might do it by increasing insulin and insulin-like growth factor,” Baldwin explains. Whey encourages the production of a peptide in the gut that then stimulates production of the hormone insulin. Since, in addition to its role in blood sugar regulation, insulin is known to influence sebum production, an increase can create the perfect environment for acne.

Though the studies leave us with mere associations and a need for more conclusive research, Baldwin says that she and other dermatologists she’s spoken with have seen eliminating whey work first-hand. “Everyone I speak to has said they’ve seen this in at least two or three patients,” Baldwin says. If you add up all those unpublished cases, that’s a significant amount, she adds.

Baldwin describes two teenage patients of hers who were failing to respond to isotrentinoin after a few months on the medication. “It’s kind of unheard of for isotrentinoin to not work over three months,” she notes. The powerful anti-acne medication is usually a last resort for those who have tried every other option to no avail. In each case, when she asked the patient to stop using whey protein, their skin began to clear in about one month.

Of course, everyone is different, and foods that trigger acne in one person might not in another. “There are a ton of people consuming milk and whey protein and hideous junk food diets who don’t have acne—and vice versa,” Baldwin says.

If you can’t figure out what’s causing your breakouts and you eat whey protein, cut it out of your diet and see if you notice a difference. Baldwin suggests giving it two months to be able to notice a clear difference (or not). If you find that whey is sabotaging your skin? There are plenty of other protein alternatives out there. If you like having a convenient option, opt for plant-based powders and bars from brands like Vega (which offers both powders and snack bars) and Plnt by Vitamin Shoppe—both use plant proteins like pea and hempseed instead.

MIllie- My recommendation is Spirulina powder.

Forget Counting Calories, Fat and Sugar – Taking Care of your Gut is What Matters

In weight loss, calorie counting and exercise have almost no impact on weight loss. Truly nourishing yourself and making sure your are actually absorbing nutrients is crucial.

From Independent–   Geneticist Professor Tim Spector wants to transform how we approach eating

Ditching restrictive dieting and calorie-counting is the key to maintaining a healthy weight according to a leading scientist determined to change how we eat.

Instead, the secret to health is nurturing the microbes in our guts, according to Professor Tim Spector, a geneticist at King’s College London. 

Professor Spector told The Independent that counting sugar, fat and calories is the wrong way to approach food.  “Eat as much as you want, just think of your microbes,” he says. 

“We have about 100 trillion microbes inside our body in the lower intestine or colon and a microbe is anything you need a microscope to see. We generally talk about bacteria, but there are viruses and fungi too and they all contribute to our health.”

Microbes help to digest food, are crucial to the immune system, and provide about a third of the body’s vitamins and chemicals. The food a person eats affects the health of their microbiome, with emerging research suggesting it can change our body’s response to medication, too. 

“We are all unique in our microbes, which explains why we respond differently to foods,” explains Professor Spector. 

There are three rules that everyone can following, Professor Spector says, to promote a diverse microbiome: eat real food that is not processed, increase fiber intake, and have a diverse diet. 

“You don’t have to cut anything out of your diet. I’m against excluding real food,” he stresses. 

The average person can, therefore, eat dairy, small amounts of meat, and carbohydrates. The best diet is one that is varied, and doesn’t include the same foods every day. 

Changes in the Diet Affect Epigenetics Via the Microbiota

In other words- EAT for Fruits and Veggies- and plenty of them. No, suppleness DO NOT take the place of real, live food!

You are what you eat, the old saying goes, but why is that so? Researchers have known for some time that diet affects the balance of microbes in our bodies, but how that translates into an effect on the host has not been understood. Now, research in mice is showing that microbes communicate with their hosts by sending out metabolites that act on histones–thus influencing gene transcription not only in the colon but also in tissues in other parts of the body. The findings publish November 23 in Molecular Cell.

“This is the first of what we hope is a long, fruitful set of studies to understand the connection between the microbiome in the gut and its influence on host health,” says John Denu, a professor of biomolecular chemistry at the University of Wisconsin, Madison, and one of the study’s senior authors. “We wanted to look at whether the gut microbiota affect epigenetic programming in a variety of different tissues in the host.” These tissues were in the proximal colon, the liver, and fat tissue.

In the study, the researchers first compared germ-free mice with those that have active gut microbes and discovered that gut microbiota alter the host’s epigenome in several tissues. Next, they compared mice that were fed a normal chow diet to mice fed a Western-type diet–one that was low in complex carbohydrates and fiber and high in fat and simple sugars. Consistent with previous studies from other researchers, they found that the gut microbiota of mice fed the normal chow diet differed from those fed the Western-type diet.

“When the host consumes a diet that’s rich in complex plant polysaccharides (such as fiber), there’s more food available for microbes in the gut, because unlike simple sugars, our human cells cannot use them,” explains Federico Rey, an assistant professor of bacteriology at UW-Madison and the study’s other senior author.

Furthermore, they found that mice given a Western diet didn’t produce certain metabolites at the same levels as mice who ate the healthier diet. “We thought that those metabolites–the short-chain fatty acids acetate, propionate, and butyrate, which are mostly produced by microbial fermentation of fiber–may be important for driving some of the epigenetic effects that we observed in mouse tissues,” Denu says.

The next step was to connect changes in metabolite production to epigenetic changes. When they looked at tissues in the mice, they found differences in global histone acetylation and methylation based on which diet the mice consumed. “Our findings suggest a fairly profound effect on the host at the level of chromatin alteration,” Denu explains. “This mechanism affects host health through differential gene expression.”

To confirm that the metabolites were driving the epigenetic changes, the investigators then exposed germ-free mice to the three short-chain fatty acids via their drinking water to determine if these substances alone were enough to elicit the epigenetic changes. After looking at the mice’s tissues, they found that the epigenetic signatures in the mice with the supplemented water mimicked the mice that were colonized by the microbes that thrive on the healthy diet.

Additional work needs to be done to translate these findings from mice into humans. “Obviously that’s a complex task,” Denu says. “But we know that human microbial communities also generate these short-chain fatty acids, and that you find them in the plasma in humans, so we speculate the same things are going on.”

Rey adds that butyrate-producing bacteria tend to occur at lower levels in people with diabetes and cardiovascular disease, and butyrate is also thought to have anti-inflammatory effects in the intestine.

But the investigators don’t advocate supplementing the diet with short-chain fatty acids as a way around eating healthy. “Fruits and vegetables are a lot more than complex polysaccharides,” Rey says. “They have many other components, including polyphenols, that are also metabolized in the gut and can potentially affect chromatin in the host in ways that we don’t yet understand. Short-chain fatty acids are the tip of the iceberg, but they’re not the whole story.”

###

This research was funded by the National Institutes of Health.

11/16/2016, Krautkramer et al: “Diet-microbiota interactions mediate global epigenetic programming in multiple host tissues.” http://www.cell.com/molecular-cell/fulltext/S1097-2765(16)30670-0

Molecular Cell (@MolecularCell), published by Cell Press, is a bimonthly journal that focuses on analyses at the molecular level, with an emphasis on new mechanistic insights. The scope of the journal encompasses all of “traditional” molecular biology as well as studies of the molecular interactions and mechanisms that underlie basic cellular processes. Visit: http://www.cell.com/molecular-cell. To receive Cell Press media alerts, please contact press@cell.com.

Disclaimer: AAAS and EurekAlert! are not respo

You are what you eat, the old saying goes, but why is that so? Researchers have known for some time that diet affects the balance of microbes in our bodies, but how that translates into an effect on the host has not been understood. Now, research in mice is showing that microbes communicate with their hosts by sending out metabolites that act on histones–thus influencing gene transcription not only in the colon but also in tissues in other parts of the body. The findings publish November 23 in Molecular Cell.

“This is the first of what we hope is a long, fruitful set of studies to understand the connection between the microbiome in the gut and its influence on host health,” says John Denu, a professor of biomolecular chemistry at the University of Wisconsin, Madison, and one of the study’s senior authors. “We wanted to look at whether the gut microbiota affect epigenetic programming in a variety of different tissues in the host.” These tissues were in the proximal colon, the liver, and fat tissue.

In the study, the researchers first compared germ-free mice with those that have active gut microbes and discovered that gut microbiota alter the host’s epigenome in several tissues. Next, they compared mice that were fed a normal chow diet to mice fed a Western-type diet–one that was low in complex carbohydrates and fiber and high in fat and simple sugars. Consistent with previous studies from other researchers, they found that the gut microbiota of mice fed the normal chow diet differed from those fed the Western-type diet.

“When the host consumes a diet that’s rich in complex plant polysaccharides (such as fiber), there’s more food available for microbes in the gut, because unlike simple sugars, our human cells cannot use them,” explains Federico Rey, an assistant professor of bacteriology at UW-Madison and the study’s other senior author.

Furthermore, they found that mice given a Western diet didn’t produce certain metabolites at the same levels as mice who ate the healthier diet. “We thought that those metabolites–the short-chain fatty acids acetate, propionate, and butyrate, which are mostly produced by microbial fermentation of fiber–may be important for driving some of the epigenetic effects that we observed in mouse tissues,” Denu says.

The next step was to connect changes in metabolite production to epigenetic changes. When they looked at tissues in the mice, they found differences in global histone acetylation and methylation based on which diet the mice consumed. “Our findings suggest a fairly profound effect on the host at the level of chromatin alteration,” Denu explains. “This mechanism affects host health through differential gene expression.”

To confirm that the metabolites were driving the epigenetic changes, the investigators then exposed germ-free mice to the three short-chain fatty acids via their drinking water to determine if these substances alone were enough to elicit the epigenetic changes. After looking at the mice’s tissues, they found that the epigenetic signatures in the mice with the supplemented water mimicked the mice that were colonized by the microbes that thrive on the healthy diet.

Additional work needs to be done to translate these findings from mice into humans. “Obviously that’s a complex task,” Denu says. “But we know that human microbial communities also generate these short-chain fatty acids, and that you find them in the plasma in humans, so we speculate the same things are going on.”

Rey adds that butyrate-producing bacteria tend to occur at lower levels in people with diabetes and cardiovascular disease, and butyrate is also thought to have anti-inflammatory effects in the intestine.

But the investigators don’t advocate supplementing the diet with short-chain fatty acids as a way around eating healthy. “Fruits and vegetables are a lot more than complex polysaccharides,” Rey says. “They have many other components, including polyphenols, that are also metabolized in the gut and can potentially affect chromatin in the host in ways that we don’t yet understand. Short-chain fatty acids are the tip of the iceberg, but they’re not the whole story.”

###

This research was funded by the National Institutes of Health.

11/16/2016, Krautkramer et al: “Diet-microbiota interactions mediate global epigenetic programming in multiple host tissues.” http://www.cell.com/molecular-cell/fulltext/S1097-2765(16)30670-0

Molecular Cell (@MolecularCell), published by Cell Press, is a bimonthly journal that focuses on analyses at the molecular level, with an emphasis on new mechanistic insights. The scope of the journal encompasses all of “traditional” molecular biology as well as studies of the molecular interactions and mechanisms that underlie basic cellular processes. Visit: http://www.cell.com/molecular-cell. To receive Cell Press media alerts, please contact press@cell.com.

Disclaimer: AAAS and EurekAlert! are not respo

12 Health Benefits of Beetroot Juice

From

The beet is a bulbous, sweet root vegetable that most people either love or hate. It’s not new on the block, but it’s risen to superfood status over the last decade or so. Research shows drinking beetroot juice may benefit your health. Here’s how.

1. Helps lower blood pressure-   Beetroot juice may help lower your blood pressure. Researchers found that people who drank 8 ounces of beetroot juice daily lowered both systolic and diastolic blood pressure. Nitrates, compounds in beetroot juice that convert into nitric acid in the blood and help widen and relax blood vessels, are thought to be the cause.

2. Improves exercise stamina-  According to a small 2012 study, drinking beetroot juice increases plasma nitrate levels and boosts physical performance. During the study, trained cyclists who drank 2 cups of beetroot juice daily improved their 10-kilometer time trial by approximately 12 seconds, while also reducing their maximum oxygen output.

3. May improve muscle power in people with heart failure-  Results of a 2015 study suggest further benefits of nitrates in beetroot juice. The study showed that people with heart failure experienced a 13 percent increase in muscle power two hours after drinking beetroot juice.

4. May slow the progression of dementia-  According to a 2011 study, nitrates may help increase blood flow to the brain in older people and help slow cognitive decline. After participants consumed a high-nitrate diet which included beetroot juice, their brain MRIs showed increased blood flow in the frontal lobes. The frontal lobes are associated with cognitive thinking and behavior. More studies are needed. But the potential of a high-nitrate diet to help prevent or slow dementia is promising.

5. Helps you maintain a healthy weight-  Straight beetroot juice is low in calories and has virtually no fat. It’s a great option for your morning smoothie to give you a nutrient and energy boost as your start your day.

6. May prevent cancer-  Beets get their rich color from betalaines. Betalaines are water-soluble antioxidants. According to a 2014 study, betalaines have chemo-preventive abilities against some cancer cell lines. Betalaines are thought to be free radical scavengers that help find and destroy unstable cells in the body.

7. Good source of potassium-  Potassium is a mineral electrolyte that helps nerves and muscles function properly. If potassium levels get too low, fatigue, weakness, and muscle cramps can occur. Very low potassium may lead to life-threatening abnormal heart rhythms. Beets are rich in potassium. Drinking beetroot juice in moderation can help keep your potassium levels optimal.

8. Good source of other minerals-  Your body can’t function properly without essential minerals. Some minerals boost your immune system while others support healthy bones and teeth. Besides potassium, beetroot juice provides:

• calcium
• iron
• magnesium
• manganese
• phosphorous
• sodium
• zinc
• copper
• selenium

9. Provides vitamin C-  Beetroot juice is a good source of vitamin C. Vitamin C is an antioxidant that helps boost your immune system and protect cells from damaging free radicals. It also supports collagen production, wound healing, and iron absorption.

10. Supports your liver-  If your liver becomes overloaded due to the following, it may lead to a condition known as nonalcoholic fatty liver disease:

• a poor diet
• excessive alcohol consumption
• exposure to toxic substances
• sedentary lifestyle

Beetroot contains betaine, a substance that helps prevent or reduce fatty deposits in the liver. Betaine may also help protect your liver from toxins.

11. Good source of folate- Folate is a B vitamin that helps prevent neural tube defects such as spinal bifida and anencephaly. It may also decrease your risk of having a premature baby. Beetroot juice is a good source of folate. If you’re of childbearing age, adding folate to your diet can help you get the 600 mcg recommended amount.

12. May reduce cholesterol-  If you have high cholesterol, consider adding beetroot juice to your diet. A 2011 study on rats found that beetroot extract lowered total cholesterol and triglycerides and increased HDL (good) cholesterol. It also reduced oxidative stress on the liver. Researchers believe beetroot’s cholesterol-lowering potential is likely due to its phytonutrients like flavonoids.

Precautions-  Your urine and stools may turn red or pinkish after eating beets. This condition, known as beeturia, is harmless. But it may be startling if you don’t expect it.  If you have low blood pressure, drinking beetroot juice regularly may increase the risk of your pressure dropping too low. Monitor your blood pressure carefully.  If you’re prone to calcium oxalate kidney stones, don’t drink beetroot juice. Beets are high in oxalates, which are naturally occurring substances that form crystals in your urine. They may lead to stones.

Next steps-  Beets are healthy no matter how you prepare them. But juicing beets is a superior way to enjoy them because cooking beets reduces their nutritional profile. If you don’t like beetroot juice straight up, try adding some apple slices, mint, citrus, or a carrot to cut through the earthy taste.

If you decide to add beetroot juice to your diet, take it easy at first. Start by juicing half a small beetroot and see how your body responds. As your body adjusts, you can drink more. 

10 Smoothie Add-Ins That Fight Chronic Inflammation

From Prevention Magazine

ByALLISON YOUNG

“When inflammation becomes chronic, it’s like having the alarm bells going off in your body 24/7,” warns Michelle Babb, MS, RD, author of Anti-Inflammatory Eating for a Happy Healthy Brain. “Those signals become maladaptive and can lead to chronic disease.”

Enter smoothies—the easiest way to sneak more anti-inflammatory foodsinto your diet, if you load them with the right superfood ingredients. Here are 10 tasty additions that will elevate your blended drink to disease-fighting status. (Want to pick up some healthier habits? Sign up to get healthy living tips, slimming recipes and more delivered straight to your inbox!)

Turmeric

Turmeric is like anti-inflammatory gold. The Indian spice adds color and a sweet-bitter kick to smoothies, plus a hefty dose of anti-inflammatory flavonoids, notably curcumin, that work by lowering histamine and enzymes linked to inflammation. Studies have found that curcumin can improve brain function and even reduce arthritis pain as much as anti-inflammatory drugs. 

Pairs with: Banana, mango, carrots, orange, pineapple, coconut milk or coconut water

Acai powder

Made from freeze-dried acai berries, acai powder is packed with anthocyanins, health-promoting antioxidants that reduce inflammation and may help prevent disease. The sweet-tart dust works by suppressing pro-inflammatory cytokines, proteins that can cause inflammation and pain. The Amazonian berry also delivers inflammation-fighting fatty acids for a mood and brain boost. 

Pairs with: Kale, spinach, chocolate/cocoa, banana, almond butter

Berries

Blueberries, blackberries, raspberries, and cranberries have a super power in common: They’re packed with antioxidants to squelch inflammation-causing free radicals. “I recommend mixed berries because they each contain unique phytonutrients,” says Babb. “Blueberries get a lot of accolades, but raspberries are also high in antioxidants and contain a potent dose of ellagic acid, which is anti-inflammatory.” 

Pairs with: Banana, bananas, avocado, mango

Tart cherry juice

Tart cherry juice may relieve your aches and pains. Hailed as having the “highest anti-inflammatory content of any food” by researchers at OregonHealth & Science University, studies have shown that drinking the sour stuff can reduce muscle pain and weakness after exercise. So what’s the secret ingredient? As well as antioxidants and anthocyanins, there are 30-plus compounds in this beverage that could squash inflammation. 

Pairs with: Lime, mango, orange, coconut milk

Cocoa powder

Permission to eat chocolate, granted! Studies show that flavanol-rich cocoa can reduce the production of pro-inflammatory molecules involved in inflammation, cutting heart disease and stroke risk. What’s more, scientists from Louisiana State University found that cocoa powder is converted into molecules in our guts that reduce inflammation. Opt for regular or raw cocoa powder (skip the “Dutch process”) for the most flavanols.

Pairs with: Banana, nut butter, blueberry, cherry, acai, yogurt, matcha, coconut

“Baby kale is packed with vitamin K, which helps shut down the inflammatory process, and it’s milder than grown-up kale, so it’s easy to disguise in a smoothie,” says Babb. The little lettuce is also rich in the mineral magnesium, known to help reduce chronic inflammation. 

Pairs with: Pineapple, mango, orange, lemon, kiwi

Ginger

Ginger doesn’t just soothe an upset stomach; the slightly spicy root acts as an anti-inflammatory, too. Researchers from the University of Miami found ginger significantly reduced knee pain in patients with osteoarthritis and may even work as a natural ibuprofen. 

Pairs with: Leafy greens, lemon, coconut, pineapple, apple, chocolate

Matcha powder

Move over, green tea! Matcha, the powdered form of green tea leaves, is not only an ideal smoothie ingredient; it has 130 times more of the cancer-fighting antioxidant epigallocatechin gallate (EGCG). Studies show EGCG has an anti-inflammatory effect on immune cells and could even help treat or prevent autoimmune diseases. 

Pairs with: Peaches, mint, cocoa, coconut, vanilla